皮质类固醇即刻和迟发性过敏反应：实用指南。
Immediate and delayed allergic hypersensitivity to corticosteroids: practical guidelines.
机构信息
Department of Dermatology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium.
出版信息
Contact Dermatitis. 2012 Jan;66(1):38-45. doi: 10.1111/j.1600-0536.2011.01967.x. Epub 2011 Oct 5.
BACKGROUND
Corticosteroids (CS), anti-inflammatory drugs also widely used to treat various allergic diseases, may themselves give rise to immediate and delayed allergic hypersensitivity reactions.
OBJECTIVES
To realise an appropriate diagnostic work-up in order to determine the CS-allergic patient's sensitization/tolerance profile and define the potential replacement agents that can still be tolerated.
METHODS
Analysis of the patch test results and concomitant (cross-) reaction patterns obtained with 315 corticosteroid-allergic patients, as well as molecular modelling of molecules.
RESULTS
Proposal of a simplified classification of corticosteroids as to their allergenic properties into 3 groups, determination of two patient profiles according to steric and electrostatic properties of the molecules. Conclusion. Practical information to the medical profession in order to detect and manage such reactions is provided.
背景
皮质类固醇（CS），一种也广泛用于治疗各种过敏疾病的抗炎药物，可能会引发即刻和迟发性过敏超敏反应。
目的
进行适当的诊断评估，以确定 CS 过敏患者的致敏/耐受情况，并确定仍可耐受的潜在替代药物。
方法
分析 315 名皮质类固醇过敏患者的斑贴试验结果和伴随（交叉）反应模式，以及分子建模。
结果
根据其变应原特性将皮质类固醇简化分类为 3 组，根据分子的空间和静电特性确定两种患者特征。
结论
为了检测和管理此类反应，向医学界提供了实用信息。
Zotero 插件