Department of Anatomical sciences and Biology, Medical Faculty, Shahid Beheshti University, MC, PO Box 19395/4719, Tehran, 1985717443, Iran.
Lasers Med Sci. 2013 Feb;28(2):399-405. doi: 10.1007/s10103-012-1074-7. Epub 2012 Feb 28.
Diabetes mellitus (DM) is associated with musculoskeletal damage. Investigations have indicated that healing of the surgically tenotomized Achilles tendon was considerably augmented following low-level laser therapy (LLLT) in non-diabetic, healthy animals. The aim of the present study was to evaluate the effect of LLLT on the Achilles tendon healing in streptozotocin-induced diabetic (STZ-D) rats via a biomechanical evaluating method. Thirty-three rats were divided into non-diabetic (n = 18) and diabetic (n = 15) groups. DM was induced in the rats by injections of STZ. The right Achilles tendons of all rats were tenotomized 1 month after STZ injections. The two experimental groups (n = 6 for each group) of non-diabetic rats were irradiated with a helium-neon (He-Ne) laser at 2.9 and 11.5 J/cm(2) for ten consecutive days. The two experimental groups of diabetic rats (n = 5 for each group) were irradiated with a He-Ne laser at 2.9 and 4.3 J/cm(2) for ten consecutive days. The tendons were submitted to a tensiometric test. Significant improvements in the maximum stress (MS) values (Newton per square millimeter) were found following LLLT at 2.9 J/cm(2) in both the non-diabetic (p = 0.031) and diabetic (p = 0.019) experimental groups when compared with their control groups. LLLT at 2.9 J/cm(2) to the tenotomized Achilles tendons in the non-diabetic and diabetic rats significantly increased the strength and MS of repairing Achilles tendons in our study.
糖尿病（DM）与肌肉骨骼损伤有关。研究表明，在非糖尿病健康动物中，低水平激光疗法（LLLT）可显著增强手术切断的跟腱的愈合。本研究旨在通过生物力学评估方法评估 LLLT 对链脲佐菌素诱导的糖尿病（STZ-D）大鼠跟腱愈合的影响。33 只大鼠分为非糖尿病（n=18）和糖尿病（n=15）组。大鼠通过注射链脲佐菌素诱导糖尿病。所有大鼠的右侧跟腱在 STZ 注射后 1 个月被切断。两组非糖尿病实验大鼠（每组 n=6）连续 10 天用氦氖（He-Ne）激光照射 2.9 和 11.5 J/cm²。两组糖尿病实验大鼠（每组 n=5）连续 10 天用 He-Ne 激光照射 2.9 和 4.3 J/cm²。对肌腱进行张力测试。与对照组相比，2.9 J/cm²的 LLLT 可显著提高非糖尿病（p=0.031）和糖尿病（p=0.019）实验组的最大应力（MS）值（每平方毫米牛顿）。与对照组相比，2.9 J/cm²的 LLLT 可显著提高非糖尿病和糖尿病大鼠切断的跟腱的强度和 MS。
