Jacobs F, Abramowicz D, Vereerstraeten P, Le Clerc J L, Zech F, Thys J P
Nephrology Surgery Department, Erasme University Hospital, Brussels, Belgium.
Rev Infect Dis. 1990 Sep-Oct;12(5):740-4. doi: 10.1093/clinids/12.5.740.
Brucella endocarditis, although a rare complication of brucellosis, is the main cause of death related to this disease. This report describes a case of aortic endocarditis due to Brucella abortus in an elderly farmer with known aortic stenosis. Urgent valve replacement was performed because of progressive heart failure despite appropriate antimicrobial treatment. The infection was cured with trimethoprim-sulfamethoxazole and rifampin given for 3 months after surgery. A review of the literature reports on the 38 other cases of cured brucella endocarditis made clear the need for combined antimicrobial treatment and surgical valve replacement.
布鲁氏菌性心内膜炎虽是布鲁氏菌病的一种罕见并发症，但却是该疾病相关死亡的主要原因。本报告描述了一例患有已知主动脉瓣狭窄的老年农民因流产布鲁氏菌引发主动脉心内膜炎的病例。尽管进行了适当的抗菌治疗，但由于进行性心力衰竭，患者接受了紧急瓣膜置换手术。术后给予甲氧苄啶 - 磺胺甲恶唑和利福平联合治疗3个月，感染得以治愈。对其他38例已治愈的布鲁氏菌性心内膜炎病例的文献回顾表明，联合抗菌治疗和外科瓣膜置换是必要的。
