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[慢性红斑狼疮,亚急性皮肤型红斑狼疮]

[Chronic lupus erythematosus, subacute cutaneous lupus].

作者信息

Doutre M S, Beylot C

机构信息

Service de dermatologie, hôpital du Haut-Lévêque, CHU de Bordeaux, Pessac.

出版信息

Rev Prat. 1990 Sep 21;40(21):1930-4.

PMID:2237183
Abstract

The cutaneous manifestations of lupus erythematosus (LE) are extremely varied, and they predominate among the clinical signs of chronic LE and subacute cutaneous LE. In chronic LE, typical lesions are found in regions exposed to sunlight and consist of erythema, hyperkeratosis and skin atrophy. The skin of patients with subacute cutaneous LE is also highly sensitive to light; the lesions consist of an annular or polycyclic or sometimes psoriasiform erythemato-squamous eruption observed mainly in uncovered areas. These dermatological forms are part of the wide spectrum of "lupus". Cutaneous manifestations are often associated with systemic signs of varying type and severity and with immunological abnormalities, such as antibodies to Ro in subacute cutaneous LE, which act as markers of the disease.

摘要

红斑狼疮(LE)的皮肤表现极为多样,且在慢性LE和亚急性皮肤型LE的临床体征中占主导地位。在慢性LE中,典型病变见于暴露于阳光的部位,由红斑、角化过度和皮肤萎缩组成。亚急性皮肤型LE患者的皮肤对光也高度敏感;病变表现为环形、多环形或有时为银屑病样的红斑鳞屑疹,主要见于暴露部位。这些皮肤表现形式是“狼疮”广泛谱系的一部分。皮肤表现常与不同类型和严重程度的全身症状以及免疫异常相关,如亚急性皮肤型LE中的抗Ro抗体,其可作为疾病的标志物。

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