[Iatrogenic lupus].

Drug-related lupus accounts for about 10 p. 100 of all lupoid diseases. The main responsible drugs are antihypertensive, antiarrhythmic and anticonvulsant agents, phenothiazines and beta-blockers. Iatrogenic lupus has a better prognosis than idiopathic lupus, since renal and neurological lesions are rare and, when present, repress after the responsible drug is withdrawn. The presence of antinuclear antibodies is indispensable to the diagnosis. The detection of anti-histones and denatured anti-DNA in the absence of anti-native DNA and/or anti-SM is the usual immunological pattern of drug-related lupus.