Turgeon P W, Slamovits T L
Eye and Ear Institute of Pittsburgh, Department of Ophthalmology, University of Pittsburgh School of Medicine.
Ophthalmology. 1989 Jan;96(1):68-71. doi: 10.1016/s0161-6420(89)32941-1.
Scleritis developed in a patient using procainamide as part of a drug-induced lupus syndrome. Systemic findings, which developed after the onset of ocular signs and symptoms, included arthralgias, myalgias, weight loss, and markedly elevated antinuclear antibody (ANA) titers and antihistone titers. The clinical picture and laboratory abnormalities improved after discontinuation of the drug. Although systemic findings secondary to drug-induced lupus have been well described in the medical literature, this case represents the first detailed ophthalmologic documentation of scleritis as the presenting manifestation of procainamide-induced lupus.
一名使用普鲁卡因胺的患者发生了巩膜炎，这是药物性狼疮综合征的一部分。眼部体征和症状出现后出现的全身表现包括关节痛、肌痛、体重减轻，以及抗核抗体（ANA）滴度和抗组蛋白滴度显著升高。停药后，临床表现和实验室异常情况有所改善。尽管医学文献中已对药物性狼疮继发的全身表现进行了详尽描述，但该病例是第一份将巩膜炎作为普鲁卡因胺诱发狼疮的首发表现的详细眼科记录。
