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美国解脲脲原体种中氟喹诺酮类药物耐药的染色体突变。

Chromosomal mutations responsible for fluoroquinolone resistance in Ureaplasma species in the United States.

机构信息

Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

出版信息

Antimicrob Agents Chemother. 2012 May;56(5):2780-3. doi: 10.1128/AAC.06342-11. Epub 2012 Feb 27.

DOI:10.1128/AAC.06342-11
PMID:22371892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3346621/
Abstract

We sequenced the full lengths of the gyrA, gyrB, parC, and parE genes in 13 fluoroquinolone-resistant Ureaplasma isolates (levofloxacin MICs, 4 to 32 μg/ml) and 10 susceptible isolates (MICs ≤ 2 μg/ml). Mutations were detected in all resistant isolates but in none of the susceptible isolates. The most prevalent mutation was the S83L substitution in the ParC protein. No plasmid-mediated fluoroquinolone resistance genes were detected.

摘要

我们对 13 株氟喹诺酮耐药解脲支原体（左氧氟沙星 MIC 值为 4 至 32μg/ml）和 10 株敏感株的 gyrA、gyrB、parC 和 parE 基因全长进行了测序。所有耐药株均检测到突变，但所有敏感株均未检测到突变。最常见的突变是 ParC 蛋白中的 S83L 取代。未检测到质粒介导的氟喹诺酮耐药基因。

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Mutations in ribosomal proteins and ribosomal RNA confer macrolide resistance in human Ureaplasma spp.核糖体蛋白和核糖体 RNA 突变赋予人类解脲支原体对大环内酯类的耐药性。
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Detection and characterization of human Ureaplasma species and serovars by real-time PCR.实时 PCR 检测和鉴定人型脲原体种及血清型。
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A survey of plasmid-mediated fluoroquinolone resistance genes from Escherichia coli isolates and their dissemination in Shandong, China.中国山东大肠杆菌分离株中质粒介导氟喹诺酮耐药基因的调查及其传播。
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