Gao Zhen-Shen, Fu Ying-Xiao, Wang Jian-Duo
College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China.
Zhong Yao Cai. 2011 Oct;34(10):1615-7.
To prepare the curcumin inclusion complex and study its stability.
Beta-cyclodextrin (beta-CD) was chosen as inclusion material and orthogonal design method was used. UV-Vis spectrophotometer was used to determine the solubility and content of different samples. They were placed under conditions of light and the solution containing Fe(3+) to determine their stability.
The optimum preparation procedure were : curcumin and beta-cyclodextrin feed molar ratio of 1: 1, the concentration of ethanol was 40%, 40 degrees C inclusion temperature and 1 h reaction time.
Inclusion complex prepared under eptimal condition is stable.
制备姜黄素包合物并研究其稳定性。
选用β-环糊精（β-CD）作为包合材料，采用正交设计法。用紫外可见分光光度计测定不同样品的溶解度和含量。将它们置于光照及含Fe(3+)溶液的条件下以测定其稳定性。
最佳制备工艺为：姜黄素与β-环糊精投料摩尔比为1:1，乙醇浓度为40%，包合温度40℃，反应时间1小时。
在最佳条件下制备的包合物稳定。
