Shah Sanjeev, Yallampalli Ragini, Merkley Tricia L, McCauley Stephen R, Bigler Erin D, Macleod Marianne, Chu Zili, Li Xiaoqi, Troyanskaya Maya, Hunter Jill V, Levin Harvey S, Wilde Elisabeth A
University of Texas Southwestern Medical Center, Dallas, TX, USA.
Brain Inj. 2012;26(3):201-10. doi: 10.3109/02699052.2012.654591.
The aim was to determine if there are changes in the integrity and volume of the ventral striatum following severe traumatic brain injury (TBI) and if these changes relate to executive functioning.
This study recruited 14 participants with severe TBI (mean age: 22 years) and 15 demographically-matched controls. All participants underwent magnetic resonance imaging with diffusion tensor imaging (DTI) and volumetric analysis at 6 months post-injury. Participants with TBI underwent neuropsychological testing and the relation between imaging data and cognitive performance was examined.
Differences in DTI parameters (fractional anisotropy (FA) and apparent diffusion coefficient (ADC)) were found between participants with TBI and controls. Correlations between right and left ventral striatum ADC and the executive functioning factor of the Neurobehavioural Rating Scale-Revised (NRS-R) were found. Correlations between right ventral striatum FA and the Controlled Oral Word Association Test, Trails Making Test Part B (TMT-B) time and NRS-R executive functioning factor were also found. Volumetric analysis showed a difference only in left nucleus accumbens between TBI and control groups.
The integrity of the ventral striatum is affected following severe TBI. Decreases in executive functioning are related to damage to the ventral striatum and its associated structures.
本研究旨在确定重度创伤性脑损伤（TBI）后腹侧纹状体的完整性和体积是否发生变化，以及这些变化是否与执行功能有关。
本研究招募了14名重度TBI患者（平均年龄：22岁）和15名人口统计学匹配的对照组。所有参与者在受伤后6个月接受了磁共振成像检查，包括弥散张量成像（DTI）和体积分析。TBI患者接受了神经心理学测试，并检查了成像数据与认知表现之间的关系。
在TBI患者和对照组之间发现了DTI参数（分数各向异性（FA）和表观扩散系数（ADC））的差异。发现左右腹侧纹状体ADC与修订版神经行为评定量表（NRS-R）的执行功能因子之间存在相关性。还发现右侧腹侧纹状体FA与受控口语联想测验、连线测验B部分（TMT-B）时间和NRS-R执行功能因子之间存在相关性。体积分析显示，TBI组和对照组之间仅在左侧伏隔核存在差异。
重度TBI后腹侧纹状体的完整性受到影响。执行功能的下降与腹侧纹状体及其相关结构的损伤有关。
