Faber J, Wilde E A, Hanten G, Ewing-Cobbs L, Aitken M E, Yallampalli R, MacLeod M C, Mullins S H, Chu Z D, Li X, Hunter J V, Noble-Haeusslein L, Levin H S
a Rice University , Houston , TX , USA.
b Department of Physical Medicine and Rehabilitation.
Brain Inj. 2016;30(13-14):1635-1641. doi: 10.1080/02699052.2016.1199910. Epub 2016 Sep 28.
The long-term effects of TBI on verbal fluency and related structures, as well as the relation between cognition and structural integrity, were evaluated. It was hypothesized that the group with TBI would evidence poorer performance on cognitive measures and a decrease in structural integrity.
Between a paediatric group with TBI and a group of typically-developing children, the long-term effects of traumatic brain injury were investigated in relation to both structural integrity and cognition. Common metrics for diffusion tensor imaging (DTI) were used as indicators of white matter integrity.
Using DTI, this study examined ventral striatum (VS) integrity in 21 patients aged 10-18 years sustaining moderate-to-severe traumatic brain injury (TBI) 5-15 years earlier and 16 demographically comparable subjects. All participants completed Delis-Kaplan Executive Functioning System (D-KEFS) sub-tests.
The group with TBI exhibited lower fractional anisotropy (FA) and executive functioning performance and higher apparent diffusion coefficient (ADC). DTI metrics correlated with D-KEFS performance (right VS FA with Inhibition errors, right VS ADC with Letter Fluency, left VS FA and ADC with Category Switching).
TBI affects VS integrity, even in a chronic phase, and may contribute to executive functioning deficits.
评估创伤性脑损伤（TBI）对言语流畅性及相关结构的长期影响，以及认知与结构完整性之间的关系。研究假设为，患有TBI的组在认知测量方面表现较差，且结构完整性会降低。
在患有TBI的儿科组和一组发育正常的儿童之间，研究创伤性脑损伤与结构完整性和认知相关的长期影响。扩散张量成像（DTI）的常用指标被用作白质完整性的指标。
本研究使用DTI检查了21名年龄在10 - 18岁之间的患者的腹侧纹状体（VS）完整性，这些患者在5 - 15年前遭受了中度至重度创伤性脑损伤（TBI），并与16名人口统计学上可比的受试者进行了比较。所有参与者都完成了德利斯-卡普兰执行功能系统（D-KEFS）子测试。
患有TBI的组表现出较低的分数各向异性（FA）和执行功能表现，以及较高的表观扩散系数（ADC）。DTI指标与D-KEFS表现相关（右侧VS的FA与抑制错误相关，右侧VS的ADC与字母流畅性相关，左侧VS的FA和ADC与类别转换相关）。
即使在慢性期，TBI也会影响VS的完整性，并可能导致执行功能缺陷。
