Parízek J
Institute of Biology, Anatomy, Histology and Embryology, Department of Anatomy, Hradec Králové.
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1990;33(1):5-47.
Our study presents macroautoradiographic maps of the distribution of 3H-spiroperidol in the CNS of rat. The radioactively labeled butyrophenone neurolepticum enables in vivo after brain intraventriculo-cisternal perfusion an exacter autoradiographic localization of dopamine receptors in various regions of the brain. For the first time 3H-spiroperidol has been administered by intraventriculo-cisternal perfusion. Also original are the finding of receptor labelling by means of 3H-spiroperidol on astroglia and in the spinal grey matter.
我们的研究展示了大鼠中枢神经系统中3H-螺哌啶醇分布的宏观放射自显影片。这种放射性标记的丁酰苯类抗精神病药物能够在脑室内-脑池灌注后在体内对大脑不同区域的多巴胺受体进行更精确的放射自显影定位。3H-螺哌啶醇首次通过脑室内-脑池灌注给药。通过3H-螺哌啶醇在星形胶质细胞和脊髓灰质上进行受体标记的发现也是首次。
