Tomasović Sanja, Predojević Maja, Stanojević Milan, Bošnjak Nad Katarina
Department of Neurology, University Hospital Sveti Duh, Medical School, University of Zagreb, Sveti Duh 64, 10000 Zagreb, Croatia.
J Matern Fetal Neonatal Med. 2012 Oct;25(10):2088-92. doi: 10.3109/14767058.2012.667179. Epub 2012 Mar 27.
Cerebral palsy (CP) is a term encompassing a group of nonprogressive, noncontagious conditions causing mild, moderate or severe disorders of neurodevelopment.
Objective of this study was to analyze the possible prenatal etiological factors for the emergence of neurodevelopmental disorders (NDs) and CP from the medical records of 100 children with neuromotor disabilities who were treated in Special Hospital for Children with Neuro-developmental and Movement Disorders, Goljak, Croatia.
ND and CP were more often diagnosed in children with birth weight below 2500 g which was statistically proved at the level of significance reaching 0.05, although significant correlation was low for both parameters reaching 0.21. There are both statistically significant differences and the statistically significant correlation between the three gestational age categories within ND and CP. There were more children with the birth weight below 2500 g in the CP than in the ND group and the difference was statistically significant. In the CP group, there were more children with the lower gestational age than in the ND group, which was statistically highly significant. This difference, together with correlation is significant at the level of 0.01.
Further studies on the etiology of NDs are needed, with particular focus on the intrauterine risk factors.
脑性瘫痪(CP)是一个术语,涵盖了一组非进行性、非传染性疾病,这些疾病会导致轻度、中度或重度神经发育障碍。
本研究的目的是从在克罗地亚戈尔亚克神经发育和运动障碍儿童医院接受治疗的100名神经运动残疾儿童的病历中分析神经发育障碍(NDs)和CP出现的可能产前病因。
出生体重低于2500克的儿童中ND和CP的诊断更为常见,这在统计学上得到了证明,显著性水平达到0.05,尽管两个参数的显著相关性较低,为0.21。ND和CP内的三个胎龄类别之间存在统计学上的显著差异和显著相关性。CP组中出生体重低于2500克的儿童比ND组多,差异具有统计学意义。在CP组中,胎龄较低的儿童比ND组多,这在统计学上具有高度显著性。这种差异以及相关性在0.01水平上具有显著性。
需要对NDs的病因进行进一步研究,尤其要关注宫内危险因素。