Pedersen R S, Aunsholt N A
First University Clinic of Internal Medicine, Aarhus Municipal Hospital, Denmark.
Scand J Urol Nephrol. 1990;24(3):223-5. doi: 10.3109/00365599009180863.
Hemodialysis may protect against disease activity in Wegener's granulomatosis. We report here a 41-year-old woman with Wegener's granulomatosis, in whom renal transplantation was performed after a 10-month period of hemodialysis during which no signs of disease activity were detected. Recurrence of disease did, however, take place 2 years after renal allograft transplantation despite immunosuppressive therapy with cyclosporine A and prednisone. Reinstitution of hemodialysis and graftectomy did not improve the patient's condition but plasmapheresis and treatment with cyclophosphamide and prednisone eliminated all signs of disease within a fortnight. A proposal for better maintenance of these patients is made.
血液透析可能预防韦格纳肉芽肿的疾病活动。我们在此报告一名41岁的韦格纳肉芽肿女性患者，她在接受了10个月的血液透析且未检测到疾病活动迹象后接受了肾移植。然而，尽管使用环孢素A和泼尼松进行免疫抑制治疗，但在肾移植后2年疾病仍复发。重新进行血液透析和移植肾切除术并未改善患者状况，但血浆置换以及环磷酰胺和泼尼松治疗在两周内消除了所有疾病迹象。本文提出了更好地维持这些患者病情的建议。
