肾移植后韦格纳肉芽肿复发。环磷酰胺成功再次诱导缓解。

Recurrence of Wegener's granulomatosis after kidney transplantation. Successful re-induction of remission with cyclophosphamide.

作者信息

Steinman T I, Jaffe B F, Monaco A P, Wolff S M, Fauci A S

出版信息

Am J Med. 1980 Mar;68(3):458-60. doi: 10.1016/0002-9343(80)90121-7.

Abstract

A patient with Wegener's granulomatosis underwent successful kidney transplantation. After four years he had a recurrence of his disease while being maintained on azathiorpine. Substitution of cyclophosphamide for azathioprine resulted in a rapid remission of the Wegener's granulomatosis. Renal function has remained stable, and the patient has done well. As previous reports have suggested, it appears that cyclophosphamide is the immunosuppressive drug of choice in the treatment of Wegener's granulomatosis and that azathioprine is not as effective as cyclophosphamide in the treatment of this form of systemic vasculitis.

摘要

一名患有韦格纳肉芽肿病的患者接受了成功的肾移植手术。四年后，他在服用硫唑嘌呤维持治疗期间疾病复发。用环磷酰胺替代硫唑嘌呤后，韦格纳肉芽肿病迅速缓解。肾功能一直保持稳定，患者情况良好。正如之前的报告所表明的那样，环磷酰胺似乎是治疗韦格纳肉芽肿病的首选免疫抑制药物，而硫唑嘌呤在治疗这种系统性血管炎方面不如环磷酰胺有效。