Rosenstein E D, Ribot S, Ventresca E, Kramer N
Division of Nephrology, Neward Beth Israel Medical Center, NJ.
Br J Rheumatol. 1994 Sep;33(9):869-71. doi: 10.1093/rheumatology/33.9.869.
A 43-yr-old man with a 19-yr history of Wegener's granulomatosis presented with recurrent haematuria, pulmonary infiltrate, cutaneous vasculitis, nasal mucosal involvement and elevation of ANCA levels, 2 yr following successful cadaveric renal transplantation, despite continued immunosuppressive therapy with cyclosporine, azathioprine and prednisone. Re-introduction of cyclophosphamide therapy resulted in prompt resolution of clinical and laboratory abnormalities. The superiority of cyclophosphamide over cyclosporine for maintaining suppression of Wegener's granulomatosis is substantiated in a critical review of the literature.
一名患有韦格纳肉芽肿病19年的43岁男性，在成功进行尸体肾移植2年后，尽管继续使用环孢素、硫唑嘌呤和泼尼松进行免疫抑制治疗，但仍出现反复血尿、肺部浸润、皮肤血管炎、鼻黏膜受累及抗中性粒细胞胞浆抗体（ANCA）水平升高。重新使用环磷酰胺治疗后，临床和实验室异常迅速得到缓解。对文献的批判性综述证实，环磷酰胺在维持对韦格纳肉芽肿病的抑制方面优于环孢素。
