Milenkovic Dragan, Morand Christine, Cassidy Aedin, Konic-Ristic Aleksandra, Tomás-Barberán Francisco, Ordovas José M, Kroon Paul, De Caterina Raffaele, Rodriguez-Mateos Ana
INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand, France;
INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand, France.
Adv Nutr. 2017 Jul 14;8(4):558-570. doi: 10.3945/an.116.013623. Print 2017 Jul.
Cardiometabolic disease, comprising cardiovascular diseases, type 2 diabetes, and their associated risk factors including metabolic syndrome and obesity, is the leading cause of death worldwide. Plant foods are rich sources of different groups of bioactive compounds, which might not be essential throughout life but promote health and well-being by reducing the risk of age-related chronic diseases. However, heterogeneity in the responsiveness to bioactive compounds can obscure associations between their intakes and health outcomes, resulting in the hiding of health benefits for specific population groups and thereby limiting our knowledge of the exact role of the different bioactive compounds for health. The heterogeneity in response suggests that some individuals may benefit more than others from the health effects of these bioactive compounds. However, to date, this interindividual variation after habitual intake of plant bioactive compounds has been little explored. The aim of this review is to provide an overview of the existing research that has revealed interindividual variability in the responsiveness to plant-food bioactive compound consumption regarding cardiometabolic outcomes, focusing on polyphenols, caffeine and plant sterols, and the identified potential determinants involved.
心血管代谢疾病，包括心血管疾病、2型糖尿病及其相关危险因素（如代谢综合征和肥胖症），是全球主要的死亡原因。植物性食物是不同种类生物活性化合物的丰富来源，这些化合物可能并非生命全程所必需，但可通过降低与年龄相关的慢性病风险来促进健康和幸福。然而，对生物活性化合物反应的异质性可能会掩盖它们的摄入量与健康结果之间的关联，导致特定人群组的健康益处被隐藏，从而限制了我们对不同生物活性化合物对健康的确切作用的了解。反应的异质性表明，一些个体可能比其他个体从这些生物活性化合物的健康影响中获益更多。然而，迄今为止，习惯性摄入植物生物活性化合物后的个体间差异很少被探究。本综述的目的是概述现有研究，这些研究揭示了在心血管代谢结局方面，个体对植物性食物生物活性化合物消费反应的变异性，重点关注多酚、咖啡因和植物甾醇，以及已确定的相关潜在决定因素。
