Rychter Anna Maria, Naskręt Dariusz, Zawada Agnieszka, Ratajczak Alicja Ewa, Dobrowolska Agnieszka, Krela-Kaźmierczak Iwona
Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 60-355 Poznań, Poland.
Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, 60-834 Poznań, Poland.
J Pers Med. 2021 Jun 3;11(6):505. doi: 10.3390/jpm11060505.
Atherosclerosis-considered the major cause of cardiovascular diseases (CVDs)-is strongly associated with obesity, to which it strongly contributes. Moreover, atherosclerosis is characterised by a long asymptomatic phase, and its progression can lead to serious cardiovascular (CV) events. The carotid intima-media thickness (cIMT) has been determined as a predictor of CV events, as well as a marker of subclinical atherosclerosis, and has been used in clinical trials as an alternative assessment method or a surrogate endpoint. It should be noted that several behavioural approaches can directly influence the cIMT values, and decrease or increase the CV risk. In our paper, we aimed to summarize the current knowledge regarding IMT measurement among patients with obesity as a risk group-also in terms of the obesity paradox where the diagnosis of subclinical atherosclerosis is especially essential and implements the early therapeutic approach. We also summarized behavioural, modifiable factors, such as the Mediterranean diet, the Dietary Approach to Stop Hypertension Diets, body weight reduction or the intake of micro- and macronutrients, with a particular focus on the studies where the cIMT values were one of the outcomes. In order to collect the literature data related to the presented topic, the PubMed database was explored.
动脉粥样硬化被认为是心血管疾病(CVD)的主要病因,与肥胖密切相关,且肥胖对动脉粥样硬化的发生有很大影响。此外,动脉粥样硬化的特点是长期无症状,其进展可导致严重的心血管(CV)事件。颈动脉内膜中层厚度(cIMT)已被确定为CV事件的预测指标以及亚临床动脉粥样硬化的标志物,并已在临床试验中用作替代评估方法或替代终点。需要注意的是,几种行为方式可直接影响cIMT值,从而降低或增加CV风险。在我们的论文中,我们旨在总结当前关于肥胖患者作为风险群体的IMT测量的知识,同时也涉及肥胖悖论,即亚临床动脉粥样硬化的诊断尤为重要,并实施早期治疗方法。我们还总结了行为、可改变的因素,如地中海饮食、终止高血压饮食法、体重减轻或微量和常量营养素的摄入,特别关注以cIMT值作为结果之一的研究。为了收集与本主题相关的文献数据,我们检索了PubMed数据库。