Cardiovascular Institute and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Perelman School of Medicine, 11-125 Translational Research Center, Philadelphia, Philadelphia 19104-5156, USA.
Nat Cell Biol. 2012 Feb 29;14(3):233-5. doi: 10.1038/ncb2452.
Endothelial-vascular smooth muscle cell communication has a critical role in cardiovascular homeostasis and the pathogenesis of atherosclerosis. A study now demonstrates extracellular-vesicle-mediated transfer of the atheroprotective microRNAs miR-143/145 between endothelial and vascular smooth muscle cells, providing compelling evidence that intercellular transport of miRNAs can influence a pathological process, namely atherosclerosis.
内皮-血管平滑肌细胞通讯在心血管稳态和动脉粥样硬化发病机制中具有关键作用。一项研究目前证明了细胞外囊泡介导的内皮细胞和血管平滑肌细胞之间的保护性微小 RNA（miR-143/145）的转移，这为细胞间 miRNA 转运可以影响病理过程，即动脉粥样硬化，提供了有力的证据。
