Vascular Epigenetics Group, Institute for Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University, D-60590 Frankfurt, Germany.
Cell. 2011 Sep 16;146(6):873-87. doi: 10.1016/j.cell.2011.08.039.
Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and they contribute to disease progression. Therapeutic approaches to block vascular supply have reached the clinic, but limited efficacy and resistance pose unresolved challenges. Recent insights establish how endothelial cells communicate with each other and with their environment to form a branched vascular network. The emerging principles of vascular growth provide exciting new perspectives, the translation of which might overcome the current limitations of pro- and antiangiogenic medicine.
血管形成广泛的网络，为体内所有组织提供营养。异常的血管生长和功能是癌症、缺血性和炎症性疾病的特征，它们会导致疾病进展。阻断血管供应的治疗方法已经进入临床，但疗效有限和耐药性是尚未解决的挑战。最近的研究结果确立了内皮细胞之间以及与它们的环境之间如何进行通讯以形成分支的血管网络。新兴的血管生长原则提供了令人兴奋的新视角，这些原则的转化可能克服当前促血管生成和抗血管生成药物的局限性。
