Mousley Carl J, Davison James M, Bankaitis Vytas A
Department of Cell & Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, 27599-7090, Chapel Hill, NC, USA,
Subcell Biochem. 2012;59:271-87. doi: 10.1007/978-94-007-3015-1_9.
An interface coordinating lipid metabolism with proteins that regulate membrane trafficking is necessary to regulate Golgi morphology and dynamics. Such an interface facilitates the membrane deformations required for vesicularization, forms platforms for protein recruitment and assembly on appropriate sites on a membrane surface and provides lipid co-factors for optimal protein activity in the proper spatio-temporally regulated manner. Importantly, Sec14 and Sec14-like proteins are a unique superfamily of proteins that sense specific aspects of lipid metabolism, employing this information to potentiate phosphoinositide production. Therefore, Sec14 and Sec14 like proteins form central conduits to integrate multiple aspects of lipid metabolism with productive phosphoinositide signaling.
协调脂质代谢与调节膜运输的蛋白质之间的界面对于调节高尔基体的形态和动力学是必要的。这样的界面促进了囊泡化所需的膜变形，在膜表面的适当位点形成蛋白质募集和组装的平台，并以适当的时空调节方式提供脂质辅助因子以实现最佳蛋白质活性。重要的是，Sec14和类Sec14蛋白是一类独特的蛋白质超家族，它们感知脂质代谢的特定方面，并利用这些信息增强磷脂酰肌醇的产生。因此，Sec14和类Sec14蛋白形成了核心通道，将脂质代谢的多个方面与有效的磷脂酰肌醇信号传导整合在一起。
