Mousley Carl J, Tyeryar Kimberly R, Vincent-Pope Patrick, Bankaitis Vytas A
Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7090, USA.
Biochim Biophys Acta. 2007 Jun;1771(6):727-36. doi: 10.1016/j.bbalip.2007.04.002. Epub 2007 Apr 12.
A central principle of signal transduction is the appropriate control of the process so that relevant signals can be detected with fine spatial and temporal resolution. In the case of lipid-mediated signaling, organization and metabolism of specific lipid mediators is an important aspect of such control. Herein, we review the emerging evidence regarding the roles of Sec14-like phosphatidylinositol transfer proteins (PITPs) in the action of intracellular signaling networks; particularly as these relate to membrane trafficking. Finally, we explore developing ideas regarding how Sec14-like PITPs execute biological function. As Sec14-like proteins define a protein superfamily with diverse lipid (or lipophile) binding capabilities, it is likely these under-investigated proteins will be ultimately demonstrated as a ubiquitously important set of biological regulators whose functions influence a large territory in the signaling landscape of eukaryotic cells.
信号转导的一个核心原则是对该过程进行适当控制，以便能够以良好的空间和时间分辨率检测相关信号。在脂质介导的信号传导中，特定脂质介质的组织和代谢是这种控制的一个重要方面。在此，我们综述了关于Sec14样磷脂酰肌醇转移蛋白（PITPs）在细胞内信号网络作用中的新兴证据；特别是与膜运输相关的证据。最后，我们探讨了关于Sec14样PITPs如何执行生物学功能的发展思路。由于Sec14样蛋白定义了一个具有多种脂质（或亲脂性）结合能力的蛋白质超家族，这些研究不足的蛋白质最终可能会被证明是一组普遍重要的生物调节因子，其功能影响真核细胞信号景观的大片区域。
