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系统评价:北美泌乳奶牛金黄色葡萄球菌乳房感染的最佳抗生素治疗方法是什么?

Systematic review: what is the best antibiotic treatment for Staphylococcus aureus intramammary infection of lactating cows in North America?

机构信息

Département des Sciences Cliniques, Faculté de Médecine Vétérinaire, 3200 rue Sicotte, CP 5000, St-Hyacinthe, Université de Montréal, Québec, Canada J2S 7C6.

出版信息

Vet Clin North Am Food Anim Pract. 2012 Mar;28(1):39-50, viii. doi: 10.1016/j.cvfa.2011.12.004. Epub 2012 Jan 4.

DOI:10.1016/j.cvfa.2011.12.004
PMID:22374116
Abstract

Staphylococcus aureus is the most prevalent pathogen causing intramammary infections (IMI) in dairy cattle worldwide. New treatment regimens have been evaluated to increase cure rates. A systematic review was conducted to answer this question: what is the best antibiotic treatment for S aureus IMI of lactating cows in North America? Direct comparison between studies (n = 6) was difficult since there was no clinical trial comparing all antibiotics and large variations between study protocols and enrolment and outcome definitions were observed. The best therapeutic option currently available in North America is an extended intramammary therapy for 5 to 8 days.

摘要

金黄色葡萄球菌是世界范围内导致奶牛乳腺炎最常见的病原体。人们已经评估了新的治疗方案来提高治愈率。进行了一项系统评价,以回答这个问题:对于北美的泌乳奶牛金黄色葡萄球菌乳腺炎,哪种抗生素治疗最好?由于没有临床试验比较所有抗生素,并且研究方案和纳入及结果定义之间存在很大差异,因此很难对研究进行直接比较(n = 6)。目前在北美的最佳治疗选择是 5 至 8 天的延长型乳房内治疗。

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