Department of Chemical and Biological Engineering, Koc University, Istanbul, Turkey.
J Biomed Mater Res A. 2012 May;100(5):1307-15. doi: 10.1002/jbm.a.34056. Epub 2012 Feb 28.
A novel composite material consisting of a silica aerogel core coated by a poly(ethylene) glycol (PEG) hydrogel was developed. The potential of this novel composite as a drug delivery system was tested with ketoprofen as a model drug due to its solubility in supercritical carbon dioxide. The results indicated that both drug loading capacity and drug release profiles could be tuned by changing hydrophobicity of aerogels, and that drug loading capacity increased with decreased hydrophobicity, while slower release rates were achieved with increased hydrophobicity. Furthermore, higher concentration of PEG diacrylate in the prepolymer solution of the hydrogel coating delayed the release of the drug which can be attributed to the lower permeability at higher PEG diacrylate concentrations. The novel composite developed in this study can be easily implemented to achieve the controlled delivery of various drugs and/or proteins for specific applications.
研制了一种由二氧化硅气凝胶核和聚乙二醇（PEG）水凝胶涂层组成的新型复合材料。由于其在超临界二氧化碳中的溶解度，以酮洛芬为模型药物测试了这种新型复合材料作为药物传递系统的潜力。结果表明，通过改变气凝胶的疏水性可以调节药物的载药量和药物释放曲线，药物载药量随疏水性的降低而增加，而疏水性的增加则导致释放速度减慢。此外，在水凝胶涂层的预聚物溶液中，PEG 二丙烯酸酯的浓度越高，药物的释放越延迟，这可以归因于在较高的 PEG 二丙烯酸酯浓度下渗透率较低。本研究开发的新型复合材料可方便地实现各种药物和/或蛋白质的控制释放，以满足特定应用的需求。
