Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, USA.
Protein Sci. 2012 May;21(5):655-66. doi: 10.1002/pro.2050. Epub 2012 Mar 29.
All acyl carrier protein primary and tertiary structures were gathered into the ThYme database. They are classified into 16 families by amino acid sequence similarity, with members of the different families having sequences with statistically highly significant differences. These classifications are supported by tertiary structure superposition analysis. Tertiary structures from a number of families are very similar, suggesting that these families may come from a single distant ancestor. Normal vibrational mode analysis was conducted on experimentally determined freestanding structures, showing greater fluctuations at chain termini and loops than in most helices. Their modes overlap more so within families than between different families. The tertiary structures of three acyl carrier protein families that lacked any known structures were predicted as well.
所有酰基辅酶 A 蛋白的一级和三级结构都被收集到 ThYme 数据库中。根据氨基酸序列的相似性将它们分为 16 个家族，不同家族的成员序列具有统计学上显著差异。这些分类得到了三级结构叠加分析的支持。一些家族的三级结构非常相似，这表明这些家族可能来自于一个单一的远祖。对实验确定的自由态结构进行了正常振动模式分析，结果表明在链末端和环处的波动比在大多数螺旋处更大。它们的模式在家族内重叠更多，而在不同家族之间重叠较少。还预测了三个缺乏已知结构的酰基辅酶 A 蛋白家族的三级结构。
