Department of Odontology, Division of Molecular Periodontology, Faculty of Medicine, Umeå University, Umeå, Sweden.
J Periodontol. 2012 Dec;83(12):1520-8. doi: 10.1902/jop.2012.110699. Epub 2012 Mar 1.
Limited data are reported concerning the presence of A. actinomycetemcomitans and attachment loss (AL) in sub-Saharan countries. The authors investigate the carrier frequency of JP2 and non-JP2 genotypes of A. actinomycetemcomitans and the presence of AL in Ghanaian adolescents and evaluate socioeconomic conditions and oral hygiene practices.
Five hundred individuals (mean ± SD age: 13.2 ± 1.5 years) in public and private schools were interviewed about demographic characteristics and oral hygiene practices and were given a full-mouth periodontal examination. Subgingival plaque samples were obtained from periodontal sites around permanent first molars and incisors. The carrier status of A. actinomycetemcomitans at the individual level was determined based on results obtained by cultivation and polymerase chain reaction.
The findings of this study show a relatively high carrier rate of JP2 and non-JP2 genotypes of Aggregatibacter actinomycetemcomitans in the Ghanaian adolescent population and the presence of this bacterium is associated with the occurrence of AL. The overall carrier rate of A. actinomycetemcomitans was 54.4%, and the highly leukotoxic JP2 genotype was detected in 8.8% of the study population. A total of 107 (21.4%) individuals had ≥ 1 tooth with AL ≥ 3 mm. The majority of the individuals carrying A. actinomycetemcomitans (80.1%) (P <0.001) and of the periodontally diseased individuals (91.6%) (P <0.001) were found in public schools.
A. actinomycetemcomitans and AL were frequently found in Ghanaian adolescents. The school type was the strongest predictor of both presence of A. actinomycetemcomitans and AL.
有关在撒哈拉以南国家中存在伴放线放线杆菌（A. actinomycetemcomitans）和附着丧失（AL）的数据有限。作者调查了加纳青少年中伴放线放线杆菌 JP2 和非 JP2 基因型的携带频率以及 AL 的存在情况，并评估了社会经济状况和口腔卫生习惯。
在公立和私立学校中，对 500 名个体（平均年龄 ± 标准差：13.2 ± 1.5 岁）进行了人口统计学特征和口腔卫生习惯的访谈，并进行了全口牙周检查。从恒牙第一磨牙和切牙的牙周部位获得龈下菌斑样本。根据培养和聚合酶链反应的结果确定个体水平上伴放线放线杆菌的携带状态。
本研究的结果表明，加纳青少年人群中 JP2 和非 JP2 基因型的伴放线放线杆菌携带率相对较高，且该细菌的存在与 AL 的发生有关。伴放线放线杆菌的总携带率为 54.4%，高度白细胞毒素 JP2 基因型在研究人群中的检出率为 8.8%。共有 107 名（21.4%）个体至少有 1 颗牙齿的 AL ≥ 3mm。携带伴放线放线杆菌的个体（80.1%）（P<0.001）和牙周病患者（91.6%）（P<0.001）大多数都在公立学校。
在加纳青少年中，伴放线放线杆菌和 AL 经常被发现。学校类型是伴放线放线杆菌和 AL 存在的最强预测因素。
