Sevastik J, Agadir M, Sevastik B
Department of Orthopaedic Surgery, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
Spine (Phila Pa 1976). 1990 Aug;15(8):826-9.
Three intercostal nerves on the right side of growing rabbits were resected partially. From 1 to 3 months later, moderate left-convex thoracic scoliosis with rotation of vertebrae had developed, and the sagittal curvatures of the spine had diminished. In one group of these animals, a mechanically produced increase of 1 cm in the length of one rib on the side of the convexity resulted in an immediate correction of the scoliotic deformity, an improvement that was still evident 3 weeks after the operation. In two other groups of rabbits, a further resection of three intercostal nerves, this time on the left convex side, 1 and 2 months after the first operation, resulted in regression of scoliosis or halted its progression. These results further support a new concept in which the precipitating factor in the development of scoliosis is ascribed to asymmetric longitudinal growth of the ribs. They also suggest that regulation of the rib length could be a promising approach to the effective correction of progressive scoliosis at an early stage in man.
对生长中的兔子右侧的三条肋间神经进行部分切除。术后1至3个月，出现了中度的左侧凸胸段脊柱侧弯并伴有椎体旋转，脊柱的矢状面弯曲度减小。在其中一组动物中，在凸侧人为使一根肋骨长度增加1厘米，结果脊柱侧弯畸形立即得到矫正，且术后3周仍有明显改善。在另外两组兔子中，在首次手术后1个月和2个月，再次切除左侧凸侧的三条肋间神经，结果脊柱侧弯消退或停止进展。这些结果进一步支持了一个新的概念，即脊柱侧弯发展的诱发因素归因于肋骨的不对称纵向生长。它们还表明，调节肋骨长度可能是在人类早期有效矫正进行性脊柱侧弯的一种有前景的方法。
