Agadir M, Sevastik B, Sevastik J A, Persson A, Isberg B
Department of Orthopaedic Surgery, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
Spine (Phila Pa 1976). 1988 Sep;13(9):1065-9. doi: 10.1097/00007632-198809000-00016.
Growing rabbits were subjected to surgical resection of the intercostal nerves on the right side, posteriorly or anteriorly. Two other groups of animals were used as sham and as normal controls. Six months after the nerve resection, there was no electromyographic evidence of denervation of the involved muscles. Radiologic examinations revealed progressive development of a curve, convex to the left, in each animal of the two resection groups. Analysis of structural changes by computed tomography showed rotation of the apical vertebra about the longitudinal axis. Rib cage deformity was diagnosed in 82% of the rabbits. The experimental model developed for induction of scoliosis is simple. The surgical procedure involves just one selected and easily recognized anatomic structure, leaving the vertebral structures and their vicinity intact. Reliable analysis of the underlying mechanism of the developing scoliosis is thereby assured.
对生长中的兔子进行右侧肋间神经的手术切除，切除部位为后侧或前侧。另外两组动物用作假手术组和正常对照组。神经切除六个月后，未发现受累肌肉有去神经支配的肌电图证据。放射学检查显示，两个切除组的每只动物均出现了向左凸的脊柱侧弯曲线，并逐渐发展。计算机断层扫描对结构变化的分析显示，顶椎围绕纵轴旋转。82%的兔子被诊断出有胸廓畸形。所建立的用于诱导脊柱侧弯的实验模型很简单。手术过程仅涉及一个选定且易于识别的解剖结构，而使椎体结构及其周围区域保持完整。从而确保了对脊柱侧弯发生机制进行可靠的分析。
