Agadir M, Sevastik B, Sevastik J A, Svensson L
Department of Orthopaedic Surgery, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
J Orthop Res. 1989;7(5):690-5. doi: 10.1002/jor.1100070509.
Two, three, or four intercostal nerves with their vasoconstrictive sympathetic fibers were resected on the right side of 15 growing rabbits. Animals submitted to sham operations and intact animals formed two control groups. A scintigraphic study with 99mTc-methylene diphosphonate, performed on the test group 2 months after the resection, showed a significantly greater uptake of the isotope on the right than on the left costochondral junctions (p less than 0.05). Three months later the difference was still larger. There was no such significant difference in the rabbits of the two reference groups. In the rabbits of both these groups, the right and left ribs of each pair were almost equal in length. Of the denervated ribs of the rabbits composing the test group, the right ribs increased in length to a greater extent than the corresponding left ribs. The difference was statistically significant (p less than 0.05). As a consequence of this left-right difference in length, mild thoracic scoliosis convex to the left developed 2 months after the resection. The total weight and volume of the denervated right ribs increased significantly more than those of the corresponding control left ribs (p less than 0.05), but their mineral content per unit of weight or volume showed no significant difference.
在15只生长中的家兔右侧切除两根、三根或四根肋间神经及其血管收缩性交感神经纤维。接受假手术的动物和完整无损的动物构成两个对照组。在切除术后2个月对试验组进行的锝-亚甲基二膦酸盐闪烁扫描研究显示，右侧肋软骨结合处对同位素的摄取明显高于左侧（p<0.05）。3个月后，差异仍然更大。两个参照组的家兔没有这种显著差异。在这两组家兔中，每对肋骨的左右长度几乎相等。在构成试验组的家兔的去神经支配肋骨中，右侧肋骨的长度增加幅度大于相应的左侧肋骨。差异具有统计学意义（p<0.05）。由于这种左右长度差异，切除术后2个月出现了向左侧凸出的轻度胸椎侧凸。去神经支配的右侧肋骨的总重量和体积比相应的对照左侧肋骨显著增加更多（p<0.05），但其每单位重量或体积的矿物质含量没有显著差异。
