Yoshino S, Fujimori J, Kajino A, Hara I
Department of Joint Disease, Nippon Medical School, Tokyo.
Ryumachi. 1990 Apr;30(2):99-102.
Nine patients with Heberden's nodes of premenopausal onset were studied for complications in the form of thyroid disorders as well as from the hereditary, roentgenological and immunological aspects. In addition, rheumatoid arthritis, psoriatic arthritis, traumatic arthritis, erosive osteoarthritis or adult Still's disease was excluded in these patients. All patients had thyroid disorder (Basedow's disease in 6 patients, Hashimoto's thyroiditis in 2 patients and granular thyroiditis in one patient). Immunological examinations were positive for anti-thyroglobulin antibody in 5 patients and anti-microsome antibody in 3 patients and anti-nuclear antibody in 2 patients. Roentgenological findings revealed no typical signs of primary generalized osteoarthritis.
对9例绝经前发病的赫伯登结节患者，从甲状腺疾病并发症以及遗传、放射学和免疫学方面进行了研究。此外，排除了这些患者中的类风湿性关节炎、银屑病关节炎、创伤性关节炎、侵蚀性骨关节炎或成人斯蒂尔病。所有患者均患有甲状腺疾病（6例为突眼性甲状腺肿，2例为桥本甲状腺炎，1例为肉芽肿性甲状腺炎）。免疫检查发现，5例患者抗甲状腺球蛋白抗体呈阳性，3例患者抗微粒体抗体呈阳性，2例患者抗核抗体呈阳性。放射学检查结果未显示原发性全身性骨关节炎的典型征象。
