The Ritchie Centre, Monash Institute of Medical Research, Clayton, Vic., Australia.
Neuroendocrinology. 2012;96(1):13-23. doi: 10.1159/000336378. Epub 2012 Feb 29.
Pregnancies complicated by impaired placentation, acute severe reductions in oxygen supply to the fetus, or intrauterine infection are associated with oxidative stress to the mother and developing baby. Such oxidative stress is characterized as an upregulation in the production of oxidative or nitrative free radicals and a concomitant decrease in the availability of antioxidant species, thereby creating a state of fetoplacental oxidative imbalance. Recently, there has been a good deal of interest in the potential for the use of antioxidant therapies in the perinatal period to protect the fetus, particularly the developing brain, against oxidative stress in complications of pregnancy and birth. This review will examine why the immature brain is particularly susceptible to oxidative imbalance and will provide discussion on antioxidant treatments currently receiving attention in the adult and perinatal literature - allopurinol, melatonin, α-lipoic acid, and vitamins C and E. In addition, we aim to address the interaction between oxidative stress and the fetal inflammatory response, an interaction that may be vital when proposing antioxidant or other neuroprotective strategies.
妊娠合并胎盘功能障碍、胎儿严重急性缺氧或宫内感染与母体和胎儿发育过程中的氧化应激有关。这种氧化应激的特点是氧化或硝化自由基的产生上调，同时抗氧化物质的可用性下降，从而导致胎盘中的氧化失衡状态。最近，人们对围产期使用抗氧化治疗来保护胎儿，特别是发育中的大脑，免受妊娠和分娩并发症中的氧化应激的兴趣大增。这篇综述将探讨为什么未成熟的大脑特别容易受到氧化失衡的影响，并将讨论目前在成人和围产期文献中受到关注的抗氧化治疗方法——别嘌醇、褪黑素、α-硫辛酸和维生素 C 和 E。此外，我们旨在解决氧化应激与胎儿炎症反应之间的相互作用，当提出抗氧化或其他神经保护策略时，这种相互作用可能至关重要。
