Pediatric Dermatology Unit, University of Padua Via Cesare Battisti 206, IT-35128 Padova, Italy.
Acta Derm Venereol. 2012 Jul;92(4):411-5. doi: 10.2340/00015555-1316.
Patients who have received liver transplant are at increased risk of skin complications due to long-term immunosuppression regimen. The aim of this study was to analyze the incidence and risk factors of skin complications in liver transplant patients. We analyzed 161 liver transplant recipients. The mean age at transplantation was 47.4 years. Mean follow-up was 6 years. Seventy-one percent of patients presented with skin complications, including aestethic alterations, infections, precancerous lesions and malignancies, which represented 57%, 43%, 18% and 9%, respectively. Risk factors were: age at transplantation ≥ 45 years, immunosuppressive therapy with cyclosporine, and phototype II and III. Our study indicates that although liver transplant recipients are at greater risk of developing skin complications compared to the general population, the risk is lower than for other solid organ transplants, particularly for premalignant and malignant lesions.
接受肝移植的患者由于长期免疫抑制方案，皮肤并发症的风险增加。本研究旨在分析肝移植患者皮肤并发症的发生率和危险因素。我们分析了 161 例肝移植受者。移植时的平均年龄为 47.4 岁。平均随访 6 年。71%的患者出现皮肤并发症，包括美容改变、感染、癌前病变和恶性肿瘤，分别占 57%、43%、18%和 9%。危险因素包括：移植时年龄≥45 岁、环孢素免疫抑制治疗以及 II 型和 III 型光型。我们的研究表明，尽管与普通人群相比，肝移植受者发生皮肤并发症的风险更高，但风险低于其他实体器官移植，特别是对于癌前病变和恶性病变。
