Department of Organic Chemistry A. Mangini, Faculty of Industrial Chemistry, University of Bologna, V. Risorgimento 4, 40136 Bologna, Italy.
Org Biomol Chem. 2012 Apr 21;10(15):2911-22. doi: 10.1039/c2ob07037e. Epub 2012 Mar 1.
Several small organic molecule catalysts are reminiscent of natural enzymes in their mode of action and substrate interaction/activation. This striking similarity has been a great source of inspiration for the development of new organocatalytic asymmetric processes. A few representative examples, mostly dealing with catalysts interacting through multiple hydrogen-bonds (synthetic oxyanion holes), are highlighted in this perspective.
几种小分子有机催化剂在作用模式和底物相互作用/活化方面类似于天然酶。这种惊人的相似性为开发新的有机催化不对称反应提供了很大的灵感。本文重点介绍了几个具有代表性的例子，这些例子主要涉及通过多个氢键（合成阴离子空穴）相互作用的催化剂。
