Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu, China.
Adv Mater. 2012 Apr 10;24(14):1868-72. doi: 10.1002/adma.201104964. Epub 2012 Feb 29.
In this work, a nanoscale reduced graphene oxide-iron oxide nanoparticle (RGO-IONP) complex is noncovalently functionalized with polyethylene glycol (PEG), obtaining a RGO-IONP-PEG nanocomposite with excellent physiological stability, strong NIR optical absorbance, and superparamagnetic properties. Using this theranostic nanoprobe, in-vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for effective photothermal ablation of tumors in mice.
在这项工作中，通过非共价键功能化的方法将纳米级还原氧化石墨烯-氧化铁纳米粒子（RGO-IONP）复合物与聚乙二醇（PEG）结合，得到具有优异生理稳定性、强近红外光吸收和超顺磁性的 RGO-IONP-PEG 纳米复合材料。利用这种治疗诊断纳米探针，进行了体内三模态荧光、光声和磁共振成像，揭示了高被动肿瘤靶向性，进一步用于有效治疗小鼠肿瘤的光热消融。
