Xie Dong, Sun Linglin, Wu Manxiang, Li Qiang
Department of Radiology, The Affiliated People's Hospital of Ningbo University, Ningbo, China.
Department of Radiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Oncol. 2025 Feb 7;15:1536779. doi: 10.3389/fonc.2025.1536779. eCollection 2025.
Iron-based nanomaterials (INMs), due to their particular magnetic property, excellent biocompatibility, and functionality, have been developed into powerful tools in both tumor diagnosis and therapy. We give an overview here on how INMs such as iron oxide nanoparticles, element-doped nanocomposites, and iron-based organic frameworks (MOFs) display versatility for tumor imaging and therapy improvement. In terms of imaging, INMs improve the sensitivity and accuracy of techniques such as magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) and support the development of multimodal imaging platforms. Regarding treatment, INMs play a key role in advanced strategies such as immunotherapy, magnetic hyperthermia, and synergistic combination therapy, which effectively overcome tumor-induced drug resistance and reduce systemic toxicity. The integration of INMs with artificial intelligence (AI) and radiomics further expands its capabilities for precise tumor identification, and treatment optimization, and amplifies treatment monitoring. INMs now link materials science with advanced computing and clinical innovations to enable next-generation cancer diagnostics and therapeutics.
铁基纳米材料（INMs）因其特殊的磁性、优异的生物相容性和功能性，已发展成为肿瘤诊断和治疗的有力工具。在此，我们概述了氧化铁纳米颗粒、元素掺杂纳米复合材料和铁基有机框架（MOFs）等铁基纳米材料如何在改善肿瘤成像和治疗方面展现出多功能性。在成像方面，铁基纳米材料提高了磁共振成像（MRI）和光声成像（PAI）等技术的灵敏度和准确性，并支持多模态成像平台的发展。在治疗方面，铁基纳米材料在免疫疗法、磁热疗法和协同联合疗法等先进策略中发挥关键作用，有效克服肿瘤诱导的耐药性并降低全身毒性。铁基纳米材料与人工智能（AI）和放射组学的整合进一步扩展了其精确肿瘤识别、治疗优化和治疗监测的能力。铁基纳米材料现在将材料科学与先进计算和临床创新联系起来，以实现下一代癌症诊断和治疗。
