地塞米松治疗对社区获得性肺炎期间肺炎球菌抗体的形成没有影响。
Dexamethasone treatment has no effect on the formation of pneumococcal antibodies during community-acquired pneumonia.
作者信息
van Mens Suzan P, Meijvis Sabine C A, Grutters Jan C, Vlaminckx Bart J M, Bos Willem J W, Rijkers Ger T
机构信息
Department of Medical Microbiology & Immunology, St. Antonius Hospital, Nieuwegein, the Netherlands.
出版信息
Clin Vaccine Immunol. 2012 May;19(5):811-3. doi: 10.1128/CVI.05697-11. Epub 2012 Feb 29.
Abstract
In this study, the effect of dexamethasone on the formation of pneumococcal antibodies during community-acquired pneumonia (CAP) was investigated. No differences between CAP patients receiving dexamethasone as additional therapy and patients receiving a placebo were found with respect to immune response rates and mean baseline and convalescent-phase antibody concentrations.
摘要
在本研究中，调查了地塞米松对社区获得性肺炎（CAP）期间肺炎球菌抗体形成的影响。在免疫反应率以及平均基线和恢复期抗体浓度方面，接受地塞米松作为附加治疗的CAP患者与接受安慰剂的患者之间未发现差异。
相似文献
1
Dexamethasone treatment has no effect on the formation of pneumococcal antibodies during community-acquired pneumonia.地塞米松治疗对社区获得性肺炎期间肺炎球菌抗体的形成没有影响。
Clin Vaccine Immunol. 2012 May;19(5):811-3. doi: 10.1128/CVI.05697-11. Epub 2012 Feb 29.
2
Dexamethasone downregulates the systemic cytokine response in patients with community-acquired pneumonia.地塞米松可下调社区获得性肺炎患者的全身细胞因子反应。
Clin Vaccine Immunol. 2012 Sep;19(9):1532-8. doi: 10.1128/CVI.00423-12. Epub 2012 Aug 1.
3
Immunity to pneumococcal surface proteins in children with community-acquired pneumonia: a distinct pattern of responses to pneumococcal choline-binding protein A.儿童社区获得性肺炎对肺炎球菌表面蛋白的免疫：对肺炎球菌结合蛋白 A 的反应模式不同。
Clin Microbiol Infect. 2011 Aug;17(8):1232-8. doi: 10.1111/j.1469-0691.2010.03389.x. Epub 2010 Dec 17.
4
A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease.肺炎球菌性肺炎后常发生非功能性调理抗体反应，并与侵袭性疾病相关。
mSphere. 2020 Feb 5;5(1):e00925-19. doi: 10.1128/mSphere.00925-19.
5
Pneumococcal conjugate vaccination response in patients after community-acquired pneumonia, differences in patients with S. pneumoniae versus other pathogens.社区获得性肺炎患者接种肺炎球菌结合疫苗后的反应，肺炎链球菌感染患者与其他病原体感染患者的差异。
Vaccine. 2017 Sep 5;35(37):4886-4895. doi: 10.1016/j.vaccine.2017.07.088. Epub 2017 Aug 9.
6
Demonstration of circulating pneumococcal immunoglobulin G immune complexes in patients with community-acquired pneumonia by means of an enzyme-linked immunosorbent assay.通过酶联免疫吸附测定法证明社区获得性肺炎患者循环中的肺炎球菌免疫球蛋白G免疫复合物。
J Clin Microbiol. 1993 Dec;31(12):3247-54. doi: 10.1128/jcm.31.12.3247-3254.1993.
7
The impact of 13-valent pneumococcal conjugate vaccination on virus-associated community-acquired pneumonia in elderly: Exploratory analysis of the CAPiTA trial.13 价肺炎球菌结合疫苗对老年人病毒相关社区获得性肺炎的影响：CAPiTA 试验的探索性分析。
Clin Microbiol Infect. 2018 Jul;24(7):764-770. doi: 10.1016/j.cmi.2017.10.006. Epub 2017 Oct 16.
8
Comparison of a pneumococcal common protein (PsaA) antibody ELISA and a PsaA immune complex ELISA for detection of pneumococcal serum antibody.用于检测肺炎球菌血清抗体的肺炎球菌常见蛋白（PsaA）抗体ELISA与PsaA免疫复合物ELISA的比较。
Pathobiology. 1998;66(2):77-83. doi: 10.1159/000028000.
9
Serologically indicated pneumococcal pneumonia in children: a population-based study in primary care settings.儿童血清学确诊的肺炎球菌肺炎：基层医疗环境中的一项基于人群的研究
APMIS. 2003 Oct;111(10):945-50. doi: 10.1034/j.1600-0463.2003.1111005.x.
10
Comparison of serological assays using pneumococcal proteins or polysaccharides for detection of Streptococcus pneumoniae infection in children with community-acquired pneumonia.比较使用肺炎球菌蛋白或多糖的血清学检测方法在儿童社区获得性肺炎中检测肺炎链球菌感染的效果。
J Immunol Methods. 2018 Sep;460:72-78. doi: 10.1016/j.jim.2018.06.011. Epub 2018 Jun 20.
引用本文的文献
1
Based on Unmodified Aptamer-Gold Nanoparticles Colorimetric Detection of Dexamethasone in Food.基于未修饰适体-金纳米粒子比色法检测食品中的地塞米松。
Biosensors (Basel). 2022 Apr 14;12(4):242. doi: 10.3390/bios12040242.
2
Association between glucocorticoids treatment and viral clearance delay in patients with COVID-19: a systematic review and meta-analysis.糖皮质激素治疗与 COVID-19 患者病毒清除延迟的关系：系统评价和荟萃分析。
BMC Infect Dis. 2021 Oct 14;21(1):1063. doi: 10.1186/s12879-021-06548-z.
3
Selection of high affinity aptamer-ligand for dexamethasone and its electrochemical biosensor.地塞米松高亲和力适体-配体的筛选及其电化学生物传感器。
Sci Rep. 2019 Apr 29;9(1):6600. doi: 10.1038/s41598-019-42671-3.
4
A Case of Long-Term Seronegative Human Immunodeficiency Virus (HIV) Infection: The Importance of the Humoral Response to HIV.长期血清阴性人类免疫缺陷病毒（HIV）感染 1 例：HIV 体液免疫应答的重要性。
Open Forum Infect Dis. 2015 Dec 23;3(1):ofv209. doi: 10.1093/ofid/ofv209. eCollection 2016 Jan.
本文引用的文献
1
Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial.地塞米松治疗社区获得性肺炎患者的疗效和住院时间：一项随机、双盲、安慰剂对照试验。
Lancet. 2011 Jun 11;377(9782):2023-30. doi: 10.1016/S0140-6736(11)60607-7. Epub 2011 Jun 1.
2
Longitudinal analysis of pneumococcal antibodies during community-acquired pneumonia reveals a much higher involvement of Streptococcus pneumoniae than estimated by conventional methods alone.社区获得性肺炎期间肺炎球菌抗体的纵向分析显示，肺炎链球菌的参与程度比仅通过传统方法估计的要高得多。
Clin Vaccine Immunol. 2011 May;18(5):796-801. doi: 10.1128/CVI.00007-11. Epub 2011 Mar 2.
3
Pathogenesis, treatment, and prevention of pneumococcal pneumonia.肺炎球菌肺炎的发病机制、治疗与预防
Lancet. 2009 Oct 31;374(9700):1543-56. doi: 10.1016/S0140-6736(09)61114-4.
4
High serological response to pneumococcal vaccine in nephrotic children at disease onset on high-dose prednisone.肾病患儿在疾病发作时接受大剂量泼尼松治疗，对肺炎球菌疫苗的血清学反应较高。
Pediatr Nephrol. 2008 Jul;23(7):1107-13. doi: 10.1007/s00467-008-0782-5. Epub 2008 Mar 7.
5
Estimating the protective concentration of anti-pneumococcal capsular polysaccharide antibodies.估算抗肺炎球菌荚膜多糖抗体的保护浓度。
Vaccine. 2007 May 10;25(19):3816-26. doi: 10.1016/j.vaccine.2007.01.119. Epub 2007 Feb 21.
6
Effects of long-term low-dose corticosteroid therapy on humoral immunity.
Ann Allergy Asthma Immunol. 2006 Jul;97(1):113-6. doi: 10.1016/S1081-1206(10)61380-4.
7
Antiinflammatory action of glucocorticoids--new mechanisms for old drugs.糖皮质激素的抗炎作用——老药的新机制
N Engl J Med. 2005 Oct 20;353(16):1711-23. doi: 10.1056/NEJMra050541.
8
Immunogenity of the pneumococcal polysaccharide vaccine in COPD patients. The effect of systemic steroids.慢性阻塞性肺疾病（COPD）患者中肺炎球菌多糖疫苗的免疫原性。全身用类固醇激素的影响。
Respir Med. 2004 Dec;98(12):1187-94. doi: 10.1016/j.rmed.2004.04.012.
9
Community-acquired pneumonia.社区获得性肺炎
Lancet. 2003 Dec 13;362(9400):1991-2001. doi: 10.1016/S0140-6736(03)15021-0.
10
Cross-reactivity of antibodies to type 6B and 6A polysaccharides of Streptococcus pneumoniae, evoked by pneumococcal conjugate vaccines, in infants.婴儿中肺炎球菌结合疫苗诱发的针对肺炎链球菌6B型和6A型多糖的抗体交叉反应性。
J Infect Dis. 2001 Sep 15;184(6):789-93. doi: 10.1086/322984. Epub 2001 Aug 14.
Zotero 插件