Kiesel P, Bodemer W, Gibson T, Zischler H, Kaup F-J
German Primate Center, Goettingen, Germany.
J Med Primatol. 2012 Jun;41(3):176-82. doi: 10.1111/j.1600-0684.2012.00535.x. Epub 2012 Mar 2.
Rhesus monkeys were used as a non-human primate model to study small non-coding RNA after infection with human sporadic and variant Creutzfeldt-Jakob prions.
Tissue-specific Alu DNA element transcription and editing of transcripts were assessed in neuronal - and blood cells (Buffy Coat).
Tissue/cell-specific transcription and editing patterns were obtained. Active Alu DNA elements belonged to several Alu DNA families, they could be located on several chromosomes, and their genomic sites were identified. Deamination by adenosine deaminase acting on RNA and apolipoprotein B editing complex was found.
Different Alu transcription and editing programmes exist and may depend on the infection status.
恒河猴被用作非人类灵长类动物模型，以研究感染人类散发性和变异型克雅氏朊病毒后的小非编码RNA。
在神经元和血细胞（血沉棕黄层）中评估组织特异性Alu DNA元件转录和转录本编辑情况。
获得了组织/细胞特异性转录和编辑模式。活跃的Alu DNA元件属于几个Alu DNA家族，它们可位于几条染色体上，并确定了其基因组位点。发现了由作用于RNA的腺苷脱氨酶和载脂蛋白B编辑复合体进行的脱氨作用。
存在不同的Alu转录和编辑程序，可能取决于感染状态。
