Bons N, Mestre-Frances N, Charnay Y, Salmona M, Tagliavini F
Ecole pratique des hautes études, Université de Montpellier II, France.
C R Acad Sci III. 1996 Aug;319(8):733-6.
This paper reports the occurrence of a spongiform encephalopathy (SE) in young adult monkeys housed in a zoological park. Three rhesus monkeys (Macaca mulatta) acquired from the same zoo and maintained on feed containing animal protein, developed a progressive neurological disorder with behavioural abnormalities and physical deterioration and died at the age of 10-year-old. Neuropathological examination of one of these animals revealed a spongiform encephalopathy similar to that observed in monkeys following experimental transmission of Creutzfeldt-Jakob disease (CJD). In particular, several brain regions exhibited vacuolation of nerve cell bodies and processes accompanied by astrogliosis. Immunohistochemical analysis showed prion protein (PrP) immunoreactivity at the periphery of vacuolated neurons. The spontaneous occurrence of a SE in these young monkeys might be related to consumption of protein of animal origin.
本文报道了在一个动物园饲养的成年幼猴中发生的一种海绵状脑病（SE）。从同一动物园获得并以含动物蛋白饲料饲养的三只恒河猴（猕猴），出现了进行性神经疾病，伴有行为异常和身体衰弱，并在10岁时死亡。对其中一只动物进行的神经病理学检查显示，其海绵状脑病与实验性传播克雅氏病（CJD）后在猴子中观察到的相似。特别是，几个脑区出现神经细胞体和突起的空泡化，并伴有星形胶质细胞增生。免疫组织化学分析显示，在空泡化神经元周边有朊病毒蛋白（PrP）免疫反应性。这些幼猴中SE的自发发生可能与食用动物源性蛋白有关。
