Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.
J Agric Food Chem. 2012 Mar 28;60(12):3086-91. doi: 10.1021/jf204447y. Epub 2012 Mar 15.
Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a fundamental regulator of systemic blood pressure. Ginsenosides from Panax ginseng have been investigated in vitro for the molecular and biochemical mechanisms by which they stimulate NO release in vascular endothelial cells; however, little research has been done to confirm the physiological relevance of these in vitro studies. To address this research gap, the effects of a P. ginseng extract rich in ginsenosides from protopanaxatriol on spontaneously hypertensive rats (SHRs) was examined. Ginseng extract administration stimulated nongenomic Akt-mediated eNOS activation, enhanced NO production, improved vessel wall thickening, and alleviated hypertension in SHRs, confirming the physiological relevance of previous in vitro studies with ginsenosides.
内皮型一氧化氮合酶（eNOS）产生的一氧化氮（NO）是全身血压的基本调节剂。已经在体外研究了人参中的人参皂苷，以研究它们刺激血管内皮细胞释放 NO 的分子和生化机制；然而，很少有研究证实这些体外研究的生理相关性。为了解决这一研究空白，研究了富含原人参三醇人参皂苷的人参提取物对自发性高血压大鼠（SHRs）的影响。人参提取物的给药刺激了非基因组 Akt 介导的 eNOS 激活，增强了 NO 的产生，改善了血管壁增厚，并缓解了 SHRs 的高血压，证实了先前关于人参皂苷的体外研究的生理相关性。
