琴叶榕桉烷倍半萜对一氧化氮生成的抑制活性。
Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
出版信息
Bioorg Med Chem Lett. 2012 Feb 15;22(4):1660-3. doi: 10.1016/j.bmcl.2011.12.114. Epub 2012 Jan 2.
Sixteen eudesmane-type sesquiterpenes including seven new compounds oxyphyllanene A-G (1-2 and 5-9) were isolated from the fruits of Alpinia oxyphylla. Among them, compounds 1-2 are novel trinoreudesmane sesquiterpenes, and 5 is a noreudesmane one. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Inhibitory activity of compounds 3-8 and 10-16 were tested against nitric oxide production in LPS and IFN-γ-induced RAW 264.7 murine macrophages, and their IC(50) values ranged from 9.85 to 13.95 μg/ml.
从益智果实中分离得到 16 个艾烷型倍半萜，包括 7 个新化合物氧石楠烯 A-G（1-2 和 5-9）。其中，化合物 1-2 为新型三降艾烷倍半萜，化合物 5 为降艾烷型倍半萜。通过波谱分析，包括二维 NMR 技术，确定了它们的结构。测试了化合物 3-8 和 10-16 对 LPS 和 IFN-γ 诱导的 RAW 264.7 鼠巨噬细胞中一氧化氮生成的抑制活性，其 IC50 值范围为 9.85-13.95μg/ml。
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