从土木香中提取的新倍半萜酸。
New sesquiterpenic acids from Inula wissmanniana.
机构信息
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, PR China.
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
出版信息
Fitoterapia. 2014 Jun;95:139-46. doi: 10.1016/j.fitote.2014.03.013. Epub 2014 Mar 29.
Eight new (1-8) and two known (9 and 10) sesquiterpenic acids featuring α-methylene-γ-carboxyl units were isolated from the whole plants of Inula wissmanniana, along with two new germacranolides (11 and 12). Their structures were elucidated based on detailed spectroscopic analysis, including HRESIMS, 1D and 2D NMR, and X-ray crystallography. Notably, the skeleton of 1 was firstly discovered from nature, while that of 2 was discovered for the second time. All the compounds were evaluated for their inhibition against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages. Compound 11 exhibited the strongest activity with the IC50 value of 1.04 μM.
从土木香全草中分离得到了 8 个新的（1-8）和 2 个已知（9 和 10）倍半萜酸，它们都具有α-亚甲基-γ-羧基单元，此外还分离得到了两个新的大根香叶烯型倍半萜内酯（11 和 12）。基于详细的光谱分析，包括高分辨质谱（HRESIMS）、1D 和 2D NMR 以及 X 射线晶体学，确定了它们的结构。值得注意的是，1 的骨架是首次从自然界中发现的，而 2 的骨架是第二次被发现。所有化合物都评估了它们对 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮（NO）产生的抑制作用。化合物 11 表现出最强的活性，IC50 值为 1.04 μM。
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