部分饱和的氟化杂环：β-三氟甲基-吡咯烷羧酸酯的非对映和对映选择性合成。
Partially saturated fluorinated heterocycles: diastereo- and enantioselective synthesis of β-trifluoromethyl-pyrroline carboxylates.
机构信息
Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Nagoya 466-8555, Japan.
出版信息
Chem Commun (Camb). 2012 Apr 14;48(30):3632-4. doi: 10.1039/c2cc18052a. Epub 2012 Mar 1.
PMID:22382646
Abstract
The first asymmetric synthesis of β-trifluoromethylated pyrroline carboxylates has been achieved by organocatalytic conjugated addition of adamantyl glycine imine to β-trifluoromethylated enones, followed by a deprotection/cyclization/dehydration sequence.
摘要
通过有机催化的金刚烷基甘氨酸亚胺与β-三氟甲基烯酮的共轭加成，再经过脱保护/环化/脱水序列，实现了β-三氟甲基化吡咯烷羧酸酯的首次不对称合成。
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