Department of Chemistry, Rhodes University, Grahamstown, South Africa.
Nat Prod Rep. 2012 May 1;29(5):513-35. doi: 10.1039/c2np00086e. Epub 2012 Mar 1.
Covering: 1972 to 2011. This review covers the literature of prenylated quinone, hydroquinone and naphthoquinone marine natural products with reported cytotoxic and/or antioxidant properties. The structures, biological activity and, where applicable, the syntheses of 159 cytotoxic/antioxidant compounds, isolated from various marine organisms, are presented, while trends in the distribution of these cytotoxic metabolites, across the different marine phyla, are highlighted. Marine prenylated quinones, hydroquinones and naphthoquinones are of mixed polyketide and terpenoid biogenesis and recent biosynthetic studies of selected compounds are discussed.
1972 年至 2011 年。本篇综述涵盖了具有细胞毒性和/或抗氧化活性的海洋天然产物中的类异戊二烯醌、对苯二酚和萘醌的文献。本文介绍了从各种海洋生物中分离得到的 159 种具有细胞毒性/抗氧化活性的化合物的结构、生物活性和（在适用的情况下）合成方法，同时强调了这些细胞毒性代谢物在不同海洋门中的分布趋势。海洋类异戊二烯醌、对苯二酚和萘醌的生物合成途径为混合的聚酮和萜烯途径，本文还讨论了选定化合物的最新生物合成研究。
