Marina A S, Kutina A V, Natochin Iu V
Ross Fiziol Zh Im I M Sechenova. 2011 Dec;97(12):1309-18.
Efficacy of drugs reduced proximal reabsorption was compared in experiments with female Wistar rats. Urine flow rate for the 1st h of experiment was enhanced after polyethylene glycol-400 (PEG) and 6% Na2SO4 infusion by over 30-fold, exenatide--40-fold, glycerol--11-fold as compared with the control. The maximal values of Na+ excretion were observed during Na2SO4 and exenatide administration (280 +/- 31 micromol/h vs. 3.2 +/- 0.6 Imol/h/100 g bw). The highest K+ excretion was revealed in experiments with glycerol administration (41 +/- 5 micromol/h vs. 7 +/- 2 micromol/h/100 g bw), Mg2+ --after exenatide injection (5.3 +/- 1.3 micromol/h vs. 0.16 +/- 0.03 micromol/ h/100 g bw). Diuretic effects were additive after combined administration of maximal doses of exenatide and PEG which suggests a different mechanism of action of solutes filtrated (PEG) to the proximal nephron segment and generated due to Na+/HW-exchange inhibition (exenatide). Osmotic diuretics differ by potency, mechanism of diuretic action and selectivity of ion excretion).
在雌性Wistar大鼠实验中比较了减少近端重吸收的药物疗效。与对照组相比，聚乙二醇-400（PEG）和6%硫酸钠输注后，实验第1小时的尿流率提高了30多倍，艾塞那肽提高了40倍，甘油提高了11倍。在给予硫酸钠和艾塞那肽期间观察到钠排泄的最大值（280±31微摩尔/小时对3.2±0.6微摩尔/小时/100克体重）。在给予甘油的实验中发现钾排泄最高（41±5微摩尔/小时对7±2微摩尔/小时/100克体重），镁排泄在注射艾塞那肽后最高（5.3±1.3微摩尔/小时对0.16±0.03微摩尔/小时/100克体重）。联合给予最大剂量的艾塞那肽和PEG后利尿作用是相加的，这表明滤过到近端肾单位段的溶质（PEG）与由于钠/氢交换抑制产生的溶质（艾塞那肽）作用机制不同。渗透性利尿剂在效力、利尿作用机制和离子排泄选择性方面存在差异。
