de la Torre J C, Carbone K M, Lipkin W I
Department of Neuropharmacology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Virology. 1990 Dec;179(2):853-6. doi: 10.1016/0042-6822(90)90154-j.
Borna disease (BD) is a neurologic syndrome characterized by profound disturbances in behavior and the accumulation of specific antigens in limbic system neurons. The potency of brain homogenates from animals with BD to cause disease in normal animals is reduced by exposure to detergents. We have recently described isolation and characterization of clones derived from the BD agent. Here we present evidence that suggests that the BD agent is a negative-sense, single-strand RNA virus. The 8.5-kb genome of this virus appears to be associated with nuclei and encodes two major RNA transcripts of 2.1 and 0.8 kb.
博尔纳病（BD）是一种神经综合征，其特征为行为严重紊乱以及边缘系统神经元中特定抗原的积累。用去污剂处理患有博尔纳病动物的脑匀浆后，其在正常动物中引发疾病的能力会降低。我们最近描述了从博尔纳病病原体中分离和鉴定克隆的过程。在此，我们提供的证据表明，博尔纳病病原体是一种负链单链RNA病毒。这种病毒8.5kb的基因组似乎与细胞核相关，并编码两条主要的RNA转录本，大小分别为2.1kb和0.8kb。
