Shih C, Yu M Y, Li L S, Shih J W
Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia 19104-6059.
Virology. 1990 Dec;179(2):871-3. doi: 10.1016/0042-6822(90)90158-n.
The human hepatitis B virus (HBV) produced by a rat hepatoma cell line through transfection with HBV DNA is infectious in the human primate model--chimpanzee. Since hepadnaviruses are known to have an extremely narrow host range, our results support the idea that the host species barrier of HBV infection resides on the penetration/adsorption step rather than any postpenetration intracellular event during the virus life cycle.
通过用乙肝病毒（HBV）DNA转染大鼠肝癌细胞系所产生的人乙肝病毒，在人类灵长类动物模型——黑猩猩中具有传染性。由于已知嗜肝DNA病毒的宿主范围极其狭窄，我们的结果支持这样一种观点，即乙肝病毒感染的宿主物种屏障存在于病毒生命周期中的穿透/吸附步骤，而非穿透后的任何细胞内事件。
