细菌性阴道病和滴虫在HIV跨女性生殖道传播中的作用。
The role of bacterial vaginosis and trichomonas in HIV transmission across the female genital tract.
作者信息
Mirmonsef Paria, Krass Laurie, Landay Alan, Spear Gregory T
机构信息
Department of Immunology/Microbiology, Rush University Medical Center, Chicago, IL 60612, USA.
出版信息
Curr HIV Res. 2012 Apr;10(3):202-10. doi: 10.2174/157016212800618165.
Abstract
Bacterial vaginosis (BV) and Trichomonas vaginalis (TV) infections are both very common and are associated with increased risk of sexual transmission of HIV. There are several mechanisms by which BV and TV could affect susceptibility including inducing pro-inflammatory cytokines and disrupting mucosal barrier function. This review highlights recent advances in our understanding of how these genital conditions lead to an increased risk of HIV infection in women.
摘要
细菌性阴道病（BV）和滴虫性阴道炎（TV）感染都非常常见，并且与艾滋病毒性传播风险增加有关。BV和TV可能通过多种机制影响易感性，包括诱导促炎细胞因子和破坏黏膜屏障功能。这篇综述重点介绍了我们在理解这些生殖器疾病如何导致女性感染艾滋病毒风险增加方面的最新进展。
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