阴道朗格汉斯细胞非生产性转运 HIV-1 介导 T 细胞感染。
Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells.
机构信息
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., D3-100, Seattle, WA 98109-1024, USA.
出版信息
J Virol. 2011 Dec;85(24):13443-7. doi: 10.1128/JVI.05615-11. Epub 2011 Oct 5.
Abstract
Although implied by other models, proof that Langerhans cells (LCs) in the human vagina participate in dissemination of infectious human immunodeficiency virus type 1 (HIV-1) has been lacking. Here, we show that LCs migrate from HIV-1-exposed vaginal epithelia and pass infectious virus to CD4+ T cells without being productively infected themselves, and we point to a pathway that might enable HIV-1 to avoid degradation in vaginal LCs. Transport by migratory LCs to local lymphatics in a nonproductive but infectious form may aid HIV-1 in evasion of topical microbicides that target its intracellular productive life cycle.
摘要
虽然其他模型暗示了人类阴道中的朗格汉斯细胞（LCs）参与了传染性人类免疫缺陷病毒 1 型（HIV-1）的传播，但缺乏证据。在这里，我们表明 LCs 从 HIV-1 暴露的阴道上皮迁移，并将感染性病毒传递给 CD4+T 细胞，而自身未被感染，我们指出了一种可能使 HIV-1 逃避阴道 LCs 降解的途径。通过迁移的 LCs 以非生产但感染性的形式运送到局部淋巴管，可能有助于 HIV-1 逃避针对其细胞内生产周期的局部杀微生物剂。
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