Department of Anatomy and Human Reproduction, PUC Minas, Belo Horizonte, Brazil.
Andrologia. 2012 Oct;44(5):355-7. doi: 10.1111/j.1439-0272.2012.01287.x. Epub 2012 Mar 5.
There has been observed a trend to delay childbearing, reflecting couple's desire to have children at older ages. Maternal age is a well-known factor that influences the achievement of a pregnancy. In contrast, there are few studies examining the effect of paternal age on the outcomes of assisted reproductive technologies (ART), and results are conflicting. Our patient was vasectomised at the age of 60 years, and his wife was 38 years old. A total of four metaphase II oocytes were inseminated 4 h later (day 0) by intracytoplasmic sperm injection using spermatozoa from percutaneous epididymal sperm aspiration. On day 2, the three resulting embryos were transferred (two had four cells, and one had two cells). Two healthy infants were born at the 37th gestational week by caesarean section. Although the effect of paternal age on ART outcomes and results are conflicting, this case report contributes to point out that advanced age of the man has probably lesser negative influence in the reproductive function.
人们观察到生育年龄推迟的趋势，这反映了夫妇希望在较晚的年龄生育孩子。母亲的年龄是影响妊娠成功的一个众所周知的因素。相比之下，很少有研究检查父亲年龄对辅助生殖技术（ART）结果的影响，而且结果相互矛盾。我们的患者在 60 岁时进行了输精管切除术，他的妻子 38 岁。总共在 4 小时后（第 0 天）通过卵胞浆内单精子注射用经皮附睾精子抽吸术获得的精子对四个中期 II 卵母细胞进行了受精。第 2 天，转移了三个胚胎（两个有四个细胞，一个有两个细胞）。通过剖腹产在第 37 个妊娠周分娩了两个健康的婴儿。尽管父亲年龄对 ART 结果和结果的影响相互矛盾，但本病例报告有助于指出男性年龄较大可能对生殖功能的负面影响较小。
