School of Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Med Chem. 2012 Mar;8(2):293-8. doi: 10.2174/157340612800493629.
Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.
最近的研究表明，穿心莲内酯是一种有潜力的抗高血脂治疗药物。本文描述了一系列穿心莲内酯衍生物的合成，并在体内评估了它们的抗高血脂活性。与 TG、TC、HDL-C 和 LDL-C 浓度相比，一些衍生物的抗高血脂效果优于阳性对照阿托伐他汀。其中，活性最强的化合物 6i 可以作为进一步开发抗高血脂药物的新先导化合物。
