Makhonova L A, Peterson I S, Zemskova V I, Pavlovskaia A I, Koposov P V
Vopr Onkol. 1990;36(9):1063-7.
The analysis of peculiarities of clinical course and morphology of malignant (acute) histiocytosis in 50 pediatric patients made a case for identification of the disease as separate pathology of histiocytic sarcoma type. Clinical course features include: lymphadenopathy, involvement of bones and--less frequently--lungs, skin and subcutaneous fat, marked fever and weight loss. Cytologic and histologic examination show polymorphic tumor cells of varying degree of differentiation, with blasts predominating. Well-developed Golgi complex, presence of lysosomes, phagosomes and erythrophagocytosis are among the characteristic ultrastructural features of the disease.
对50例儿科患者恶性（急性）组织细胞增多症的临床病程和形态学特征进行分析后，有理由将该疾病认定为组织细胞肉瘤类型的一种独立病理。临床病程特征包括：淋巴结病、骨骼受累，较少见的是肺部、皮肤和皮下脂肪受累、高热和体重减轻。细胞学和组织学检查显示不同分化程度的多形性肿瘤细胞，以原始细胞为主。发达的高尔基体、溶酶体、吞噬体的存在以及红细胞吞噬现象是该疾病的特征性超微结构特征。
